My experience with anthropomorphic animal-creatures is mostly positive, but also rather childish. I loved Saturday Morning Cartoons like Teenage Mutant Ninja Turtles and Ducktales. Creating humanoid animals and assigning them familiar human traits and livelihoods is a classic story-telling device that speaks especially well to children and young adults.
The Autumnlands: Tooth and Claw eschews most of the familiar trappings by throwing its huge variety of creatures into a far-flung future of magic spells, floating cities, and racial divides. The new series from Image Comics also contains a decidedly mature tone with language and violence akin to your favorite swords and sorcery HBO show. While the story-telling feels more suited to a traditional novel format (complete with mini-short stories accompanying each issue), the incredible artwork and intriguing world-building create a visual feast and a fun introduction to this strange new world.